Liens et agrandissements sur : images et texte en bleu. Links - Zoom: pictures and highlighted text.
  Femme de 40 ans, se plaignant d'une lésion polypoïde du palais, de consistance ferme, bien circonscrite.   40 yo female, complaining of a polypoïde mass of the palate, firm in consistancy, well circumscribed.  
  Resection chirurgicale   Surgical excision:  
  Alcian Blue   Alcian Blue - Hyaluronidase  
  Alcian Blue   Alcian Blue - Hyaluronidase  
  Alcian Blue   Alcian Blue - Hyaluronidase  

Diagnostic proposé








Mucinose orale focale


Proposed diagnosis








Focal Oral Mucinosis


dans le texte ci-dessous


In the highlighted text below


Pathology & Genetics of Head and Neck Tumours

(WHO Classification of tumours, 2005)


Focal oral mucinosis (FOM) is the oral counterpart of focal cutaneous mucinosis and cutaneous myxoid cyst. It is postulated that FOM develops as the result of a fibroblastic overproduction of hyaluronic acid due to an unknown cause.


Today, fewer than fifty cases have been reported. The lesion may occur at all
ages, but it is rare in children. There is no distinct sex predilection.


Clinical features
The clinical presentation is usually that of an otherwise asymptomatic fibrous or cystic-like lesion. The most common site is the gingiva; less common sites include the palate, cheek mucosa and tongue. The consistency may vary from soft elastic to firm.


The histopathology is characterized by a well-circumscribed area of myxomatous tissue in which fusiform or stellate fibroblasts are present. Reticular fibres are sparse or absent. The mucinous material shows alcianophilia at pH 2.5. The histologic differential diagnosis includes soft-tissue myxoma, myxomatous change in fibrous lesions, nerve sheath myxoma, and mucous retention phenomenon. The lack of reticular fibres and the sharp delineation distinguishes FOM both from soft-tissue myxoma and from myxomatous changes in fibrouslesions. Nerve sheath myxoma usually shows a lobular architecture and, conspicuously, contains numerous mast
cells. The mucous retention phenomenon is surrounded by a wall of granulation tissue or an epithelium-lined wall, while the mucoid material contains histiocytic cells; such features are lacking in FOM.


Prognosis and predictive factors
The lesion is treated by conservative surgical excision and has no tendency to recur.