School of Myology - Workshop - Class
Case No. 10
Male adult 25 yo. Progressive muscular weakness
predominantly in lower limbs. CK: 5000 U.
Dystrophic changes are observed
on HE stain (fiber necrosis, regeneration, endomysial fibrosis)
Same changes are noted on Gomori
Mosaic membrene expression pattern
in immunohistochemistry with antibodies for dystrophins.
Positivity to antibodies for
different sarcoglycans (alpha slightly decreased),
Muscular dystrophy, Becker's