Clickez sur l'image pour agrandir, ou sur les textes en gras pour visionner les imges ou les pages liés . Pour revenir à l'Observation, pressez Précédente dans votre navigateur

Click on the picture to Zoom or highlighted text to view the linked pictures or pages, . And Back on your browser to review the Observation

School of Myology - Workshop - Class 2002

Case No.4

Clinical Setting

Male adult. 30 yo. Exercise intolerance.




HE and Gomori stain demonstrate dystrophic changes (fibrosis, necrosis, regeneration)

Immunohistochemistry disclosed deficiency in the expression of alpha and gamma-sarcoglycan, confirmed by western blotting, and further genetic testing.


Proposed diagnosis

Alpha-sarcoglycanopathy consistent with a Limb Girdle Muscular Dystrophy (LGMD 2D).


Back to Workshop Index  -  Next Case