School of Myology - Workshop - Class
Female child. 5 yo. Progressive muscular weakness.
CK 2500 U.
stain shows subsarcolemmal irregular basophilic structures in
some fibers, which are fuschinophilic on Gomori
stain (Ragged Red Fibers).
Increased vacuoles are observed
to Red Oil O staining, and changes in
Cytochrome c Oxydase activity.
Similar pattern is found with
NADH and SDH, with internal structural disorganisation,
Metabolic myopathy, mitochondrial.